PUBLICATIONS
I have selected some reviews that help to understand the hypothesis. In these reviews you can find specific references to each postulate.
I have selected some reviews that help to understand the hypothesis. In these reviews you can find specific references to each postulate.
Huenchuguala S, Segura-Aguilar J. Single-neuron neurodegeneration as a degenerative model for Parkinson's disease. Neural Regen Res. 2024 Mar;19(3):529-535. doi: 10.4103/1673-5374.380878. PMID: 37721280; PMCID: PMC10581573. Link Here.
Segura-Aguilar, J.;Mannervik, B.
A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies.
Antioxidants 2023, 12, 673.
Link Here and Link Here.
Segura-Aguilar J, Muñoz P, Inzunza J, Varshney M, Nalvarte I, Mannervik B.
Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase.
Antioxidants 2022 11(2):296. doi: 10.3390/antiox11020296. PMID: 35204179; PMCID: PMC8868244.
Link Here and Link Here.
Segura-Aguilar J, Mannervik B, Inzunza J, Varshney M, Nalvarte I, Muñoz P. Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity. Neural Regen Res. 2022 Sep;17(9):1861-1866. doi: 10.4103/1673-5374.335690. PMID: 35142659; PMCID: PMC8848618.
Link Here.
Herrera A, Muñoz P, Steinbusch HWM, Segura-Aguilar J.
Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
ACS Chem Neurosci. 2017 8(4):702-711. doi: 10.1021/acschemneuro.7b00034. Epub 2017 Mar 3. PMID: 28233992.
Link Here.
Segura-Aguilar J.
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.
Neural Regen Res. 2017 12(6):897-901. doi: 10.4103/1673-5374.208560. PMID: 28761417; PMCID: PMC5514859.
Link Here.
Segura-Aguilar J, Muñoz P, Paris I. Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease.
Curr Med Chem. 2016;23(4):346-59. doi: 10.2174/0929867323666151223094103. PMID: 26695514.
Link Here.
Segura-Aguilar J.
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
Neural Regen Res. 2015 10(8):1225-7. doi: 10.4103/1673-5374.162750. PMID: 26487845; PMCID: PMC4590230.
Link Here.
Segura-Aguilar J, Paris I, Muñoz P, Ferrari E, Zecca L, Zucca FA.
Protective and toxic roles of dopamine in Parkinson's disease.
J Neurochem. 2014 129(6):898-915. doi: 10.1111/jnc.12686. Epub 2014 Mar 18. PMID: 24548101.
Link Here.
Huenchuguala S, Segura-Aguilar J. Single-neuron neurodegeneration as a degenerative model for Parkinson's disease. Neural Regen Res. 2024 Mar;19(3):529-535. doi: 10.4103/1673-5374.380878. PMID: 37721280; PMCID: PMC10581573. Link Here.
Segura-Aguilar, J.;Mannervik, B.
A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies.
Antioxidants 2023, 12, 673.
Link Here and Link Here.
Segura-Aguilar J, Muñoz P, Inzunza J, Varshney M, Nalvarte I, Mannervik B.
Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase.
Antioxidants 2022 11(2):296. doi: 10.3390/antiox11020296. PMID: 35204179; PMCID: PMC8868244.
Link Here and Link Here.
Segura-Aguilar J, Mannervik B, Inzunza J, Varshney M, Nalvarte I, Muñoz P. Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity. Neural Regen Res. 2022 Sep;17(9):1861-1866. doi: 10.4103/1673-5374.335690. PMID: 35142659; PMCID: PMC8848618.
Link Here.
Herrera A, Muñoz P, Steinbusch HWM, Segura-Aguilar J.
Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
ACS Chem Neurosci. 2017 8(4):702-711. doi: 10.1021/acschemneuro.7b00034. Epub 2017 Mar 3. PMID: 28233992.
Link Here.
Segura-Aguilar J.
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.
Neural Regen Res. 2017 12(6):897-901. doi: 10.4103/1673-5374.208560. PMID: 28761417; PMCID: PMC5514859.
Link Here.
Segura-Aguilar J, Muñoz P, Paris I. Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease.
Curr Med Chem. 2016;23(4):346-59. doi: 10.2174/0929867323666151223094103. PMID: 26695514.
Link Here.
Segura-Aguilar J.
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
Neural Regen Res. 2015 10(8):1225-7. doi: 10.4103/1673-5374.162750. PMID: 26487845; PMCID: PMC4590230.
Link Here.
Segura-Aguilar J, Paris I, Muñoz P, Ferrari E, Zecca L, Zucca FA.
Protective and toxic roles of dopamine in Parkinson's disease.
J Neurochem. 2014 129(6):898-915. doi: 10.1111/jnc.12686. Epub 2014 Mar 18. PMID: 24548101.
Link Here.